Introduction: The Covid-19 pandemic is one of the most dangerous challengethis world had faced in our recent life time. Majority of the COVID cases are mild or asymptomatic. Such cases usually recover with minimal intervention and can be managed through home isolation. For the home isolation there are some specific guidelines given by the authority of which every common man especially the medical personnel’s must know.

Objective: To assess the knowledge of students regarding revised guidelines for home isolation of covid-19 cases (mild/asymptomatic) as measured by a structured knowledge questionnaire.

Methodology: A descriptive approach was used for this study. Non experimental and descriptive survey design was adopted for this study. The sample comprised of 60 nursing students selected by simple random sampling technique. Data was collected by administering the structured knowledge questionnaire. The obtained data was analysed using descriptive statistics.

Result: The results of the study showed that majority (85%) of the students had good knowledge, (10%) of the students had average knowledge, and only (5%) of the students had excellent knowledge regarding revised guidelines for Home Isolation of COVID – 19 cases, with overall Mean % of 60.62 respectively.