The study aimed at assessing the effectiveness of a planned teaching programme on knowledge and attitude regarding post-exposure prophylaxis (PEP) for HIV among staff nurses in selected private hospitals of Ahmedabad city. A pre-experimental one-group pre-test and post-test research design was adopted. The sample consisted of 60 staff nurses selected using a non-probability convenience sampling technique. Data were collected using a structured knowledge questionnaire and a Likert’s attitude rating scale. Following the pre-test, a planned teaching programme on PEP for HIV was administered, and a post-test was conducted after seven days.

The findings revealed that prior to the intervention, 60% of nurses had poor knowledge and none had good knowledge. Post-intervention, 61.7% demonstrated good knowledge, with no participants remaining in the poor category. Regarding attitude, 75% had a favourable attitude in the pre-test, which improved to 100% favourable attitude in the post-test. The mean knowledge score increased from 13.35 (44.5%) to 23.23 (77.43%), and the mean attitude score increased from 66.15 (66.15%) to 82.65 (82.65%). Statistical analysis using paired t-tests showed significant improvements in both knowledge (t=38.591) and attitude (t=28.738) at p<0.05.

The study concludes that the planned teaching programme was effective in significantly enhancing both knowledge and attitude of staff nurses regarding PEP for HIV. It highlights the importance of educational interventions in reducing occupational risks and improving healthcare practices among nurses