Background of the study: According to the Pan American Health Organization and WHO, CKD is the 8th leading cause of mortality and the 10th cause of years of life lost and disability. More than 850 million people worldwide suffer from some form of kidney disease; among them, 5.3 and 10.5 million people require dialysis or transplantation. Patients on hemodialysis struggle with many complications. Multi-modal nursing intervention is an essential element to combat these complications and helps to improve the general well-being of the patients.

Methodology: The research design selected for the present study was pre-experimental with one group pre-test and post-test design 60 samples were obtained by probability simple random sampling technique. Structured knowledge questionnaires were used to collect the data analysis and interpretation done by using descriptive and inferential statistics

Result: The study results revealed that among 60 patients, 43(72%) had adequate knowledge, 12(20%) had moderate knowledge and 43(72%) had inadequate knowledge. The pre-test mean score with standard deviation was 8.61 +4.84 and mean percentage score was 31.61% and the post-test mean score with standard deviation was 21.87+7.04 and mean percentage score was 73.25%. The obtained ‘t’ value was 53.02 which was greater than the table value at p<0.05 level of significance.