Background: Fatigue is a common and debilitating symptom, affecting 42–89% of end-stage kidney disease patients, persisting even in pre–dialysis care and stable kidney transplantation, with huge repercussions on functioning, quality of life and patient outcomes. Fatigue is frequently experienced by patients undergoing hemodialysis and it has a negative effect on their quality of life.

Methods: This is a narrative review study in which various information banks and search motors such as PubMed, google scholar, SCOPUS, were reviewed. Hemodialysis, fatigue, ckd and ESRD keywords from cross sectional, cohort, clinical experimental studies were also used in the study construction.