Background of the study: Through these years chemotherapy nurses have mastered clinical expertise in areas which contribute to patient care.

Research Methodology: An evaluatory research approach was used to find out the effectiveness of PTP on safe handling of cancer chemotherapeutic drugs for nursing officers is pre experimental one group pre-test post-test design.

Dependent Variables: Knowledge level of nursing officers cancer chemotherapeutic drugs.

Independent Variables: Planned teaching programme.

Data Collection: Demographic variables and structured knowledge questionnaire was developed.

Results: Descriptive and inferential statistics. The effectiveness of PTP was identified using frequency and percentage. Paired‘t’ test was used to find out the significant difference between the pre-test and post-test knowledge scores and the mean post-test knowledge scores (56.5) was higher than the mean pre-test knowledge scores (21.57). The computed‘t’ value is 54.058 is higher than the tabled value t₉₉ at p<0.001 level of significance the association between pre-test knowledge scores and selected variables were calculated using Chi square test.