Background: Mechanical ventilation is a life saving therapeutic technique and frequently used treatment modality for a variety of medical diagnoses in the Intensive Care Unit (ICU). Ventilator associated pneumonia (VAP) is a common nosocomial infection occurring in 9% to 27% of mechanically ventilated patients. Nurses are the first line defense in preventing the VAP. The researcher found that together with other health care providers, nurses play a key role in preventing VAP.

Objectives: To assess the effectiveness of Nursing care bundle on prevention of ventilator associated pneumonia between experimental and control group of mechanically ventilated patients.

Design: Quasi experimental design was adopted for the study.

Setting: Dhanvantri Critical Care Center, Erode and Erode Trust Hospital.

Sample and sampling Techniques: 80 control group, 80 experimental group totally 160 patients fulfilling the inclusion criteria were selected by purposive sampling.

Methods: A Pretest was conducted by using clinical pulmonary infection score and Modified Mass Wisconsin Physical Comfort scale immediately after pretest Nursing care bundle was provided from 1st day of ventilation till 10 days for experimental group. It involves with group of nursing care activities like Position changes, Hand wash, Nebulization, Closed suction and Chlorhexidine mouth care for mechanically ventilated patients. And again Post - test was conducted to assess the effectiveness of Nursing care bundle. Collected data were analysed by using descriptive and inferential statistics.

Results: Most of the mechanically ventilated patients were in the age group of 20-30 years (53%) were female (60%), in experimental group. Most (95%) were Naso tracheally intubated in experimental group. Majority (70%) patients in VCV mode of ventilation in experimental group. (70%) subjects diagnosed as Organo Phosphorus Compound Poisoning. 38% of the subjects with Diabetes mellitus. 10 (12%) had early onset of VAP 13 (16%) and 15 (19%) respectively totally 28 patients had developed late onset of VAP in control group where as in experimental group 4 (5%) of the subjects had developed early onset, totally 11 of the subjects had developed late onset of VAP. In control group posttest I 20 (25%) experienced physical discomfort. In post test II 48 (60%) subjects were physically uncomfort. 22 (28%) were physically discomfort and 10 (12%) of the subjects experienced physical comfort. In post test III 42 (53%) of subjects were physically uncomfort. 18(22%) were physically discomfort and 20 (25%) of the subjects experienced physical comfort. In experimental group, post test I shows 58 (73%) had experienced uncomfort, 12 (15%) experienced physical discomfort and in post test I, 10 (12%) of subjects were physically comfort. In post test II 30 (37%) subjects were physically uncomfort. 28 (35%) were physically discomfort and 22 (28%) of the subjects experienced physical comfort. The overall paired t test value commensuration on clinical pulmonary infection scores evidenced distinct clinical significance (p<0.05) with experimental group (13.21). The overall paired t test value commensuration on clinical pulmonary infection scores evidenced distinct clinical significance (p<0.05) with control group (7.36). The overall paired t test value commensuration on clinical pulmonary infection scores evidenced distinct clinical significance (p<0.05) with experimental group (16.71). Unpaired‘t’ test shows that the overall score was 12.46 in clinical pulmonary infection score. 10.45 in physical comfort when compare to P value (1.960) it was high. It seems that there is significant difference in the level of Ventilator Associated Pneumonia and physical comfort among mechanically ventilated patients in control and experimental group after Nursing care bundle. Karl Pearson’s co-efficient of co-relation analysis between Ventilator Associated Pneumonia and Physical Comfort scores shows a significant relationship which reveals that when Ventilator Associated Pneumonia not developed and Physical Comfort level increases. Hence, there was a highly positive relationship between these variables. There is a significant effectiveness of nursing care bundle on prevention of ventilator associated pneumonia among mechanically ventilated patients in experimental than control group.