Introduction: Organ and tissue donation is considered as ultimate humanitarian act of service for mankind. Transplant can save or transform the life of a person. Many study results supported, well- directed educational interventions are required to sensitize young adults about organ donation.

Objectives: To determine the level of knowledge regarding organ donation. To find the effectiveness of planned teaching program on organ donation among allied health science students in terms of gain in mean post-test knowledge score. To find out association between the knowledge regarding organ donation with selected demographic variables.

Methodology: An evaluative approach was used for this study. A quasi experimental one group pre-test post-test design was adopted for this study. 60 allied health science students were selected using simple random sampling method from a selected allied health science institution at Mangalore. Baseline performa and structured knowledge questionnaire tools used and the data was analysed using descriptive and inferential statistics.

Results: The result of the study showed that, the mean post-test knowledge score obtained (13.30) was higher than the mean pre-test knowledge score (8.73). The computed ‘t’ value 9.86 (t ₅₉ = 2.02), P <0.05 showed that there was a significant difference in the pre-test post-test knowledge score. There was no significant association between mean knowledge score and selected demographic variables.