This study investigated emergency airway breathing with the optimization of oxygen fulfillment in bronchial asthma patients. It was done at TK. II Moh. Ridwan Meuraksa Hospital. The research design used was case qualitative with a case study design. The sample was two patients using the nursing care process, collaborative action of administering nasal cannula oxygen 3 liters/minute, and nebulizer therapy. Nursing self-paced measures by monitoring breathing frequency, patterns, and oxygen saturation, providing semi-fowler positions, teaching effective cough techniques, and providing warm water drinking. Independent nursing actions to overcome patient anxiety provide psychological support by listening attentively, teaching relaxation techniques, and continually encouraging families to support and accompany patients in the emergency room. Shortness of breath in both patients is reduced, sputum can be excreted with a diluted white consistency, breathing frequency improves, and oxygen saturation increases. Patient 1 respiratory frequency is 24 x / min, and oxygen saturation is 99%. Patient two respiratory frequency is 22 x / min, and oxygen saturation is 98%. The use of respiratory muscles decreases, and the patient appears more relaxed. The importance of the role of nurses in emergency installations in providing fast, swift, responsive services to overcome airway and breathing problems with oxygen fulfillment measures in Bronchial Asthma patients. In implementing nursing care, nurses need to be caring to overcome the anxiety experienced by patients and families.