Introduction: Lung cancer is a preventable and treatable disease yet its incidence and mortality are increasing every year due to lack of awareness and early detection. Objective: The present study aimed at determining the effectiveness of an educational intervention i.e. video-assisted teaching on knowledge regarding Lung Cancer and its management among under-graduate engineering students. Methods: The study utilized one group pretest-posttest quasi experimental research design to evaluate the effectiveness of a video-assisted teaching regarding lung cancer. A total of sixty selected engineering college students were selected for the study through a convenient sampling method. The data was collected by using structures self-reporting knowledge questionnaire regarding various aspects of lung cancer. Results: The majority of the undergraduate engineering students (63.33%) had inadequate knowledge and the reaming (36.77%) had moderately adequate knowledge and none of them was found to be with adequate knowledge in the pretest. After the intervention, the results demonstrated a considerable improvement in the knowledge level and it was substantially significant according to the paired t-test value of t=27.008 at a 5% level (p<0.05). Conclusion: Video-assisted teaching is an effective educational intervention increase the knowledge among students regarding various aspects of lung cancer.