Introduction: A surgical site infection (SSI) occurs after surgery, where the surgery took place, an infection develops in about 1 to 3 out of every 100 patients who have surgery². WHO reported that the prevalence of health-care-associated infections in low-income and middle-income countries was 2 to 20 times higher than in high-income countries, affecting and 66% patients who had surgery¹ Surgical site infections are among the most preventable health-care- associated infections and are a substantial burden to health-care systems and service payers worldwide in terms of patient morbidity, mortality, and additional costs.

Material and Methods: A experimental study was used to assess the effectiveness of Structured teaching programme on knowledge regarding prevention of surgical site infection among 100 staff nurses working in selected hospital at vidharbha region, Maharashtra. The sample was selected by using convenient sampling technique. The self-administered questionnaire was used to assess the knowledge of staff nurses regarding prevention of SSI. After content validity of the tool, the reliability of tool was established by using test re test method. zThe pilot study was conducted among 10 staff nurses working in selected hospital (other than study area) to find out the feasibility of major study. The investigator has obtained formal permission from Researcher Committee, Institutional Ethical committee and informed consent from each staff nurses for data collection. The investigator has fixed the data and time and data collected from investigator himself.

Results: The study finding reveals that the majority of staff nurses were found average knowledge Before intervention, had mean knowledge score of 10.6 ± 3.3 is average and After intervention, had mean knowledge score is excellent and very good 15.6 ± 4.87.