Background: Hypertension is one of the most prevalent noncommunicable diseases affecting India’s information technology (IT) workforce a population characterized by prolonged screen exposure, high cognitive demands, irregular work schedules, and sedentary lifestyles. These occupational patterns significantly elevate the risk of early-onset hypertension and related cardiovascular complications. Although nurse-led interventions have demonstrated strong efficacy in community and clinical settings, their implementation within corporate environments, particularly among IT professionals, remains limited. Moreover, gender-based differences in health behavior, adherence, and response to hypertension management have not been adequately explored in occupational health research in India.

Aim: This study aimed to evaluate the effectiveness of a structured nurse-led intervention program in managing hypertension among IT professionals in Chennai, with a specific focus on comparing gender-based outcomes in blood pressure control, medication adherence, and self-efficacy.

Methods: A quasi-experimental, pre-test/post-test design was employed involving 240 IT professionals diagnosed with hypertension (120 males and 120 females) from three major corporate organizations in Chennai. The intervention group participated in a six-week nurse-led program that included individualized lifestyle modification counseling, dietary and physical activity guidance, stress management techniques, and digital follow-up through mobile reminders and teleconsultation. The control group received routine medical care. Blood pressure, medication adherence, and self-efficacy were measured at baseline and 12 weeks using validated instruments. Data were analyzed using paired and independent t-tests, with a significance threshold set at p < 0.05.

Results: Participants in the nurse-led intervention group demonstrated a statistically significant reduction in mean systolic blood pressure (−12.6 mmHg, p < 0.001) and diastolic blood pressure (−5.3 mmHg, p < 0.01) compared with the control group. Female participants exhibited greater improvements in medication adherence and self-efficacy (p < 0.05), whereas male participants showed larger reductions in blood pressure values. These findings underscore the importance of incorporating gender-sensitive approaches into hypertension management.