Health-related misinformation in indigenous languages has become a significant challenge to healthcare delivery in rural Nigeria. With over 500 indigenous languages spoken, rural communities often rely on local dialects for communication, which enhances accessibility but also increases vulnerability to the spread of misleading health information. This study explores the influence of health-related misinformation disseminated in indigenous languages on rural healthcare choices in Nigeria. The research adopts a mixed-methods approach, combining quantitative surveys and qualitative interviews with rural residents in Nsukka, Gashua, and Ogbomosho. Findings indicate that exposure to misinformation, particularly through indigenous-language channels such as radio and community gatherings, significantly affects healthcare decisions. Those exposed to misinformation were more likely to use traditional healers, rely on herbal remedies, and avoid formal healthcare services. The study highlights the importance of culturally relevant health communication and recommends integrating indigenous languages into public health campaigns to combat misinformation and improve rural healthcare outcomes.