Objective(s): Pruritus is one of the most important and debilitating skin complications in hemodialysis (HD) patients. Therefore, this study aimed to determine the comparative effect of slow-stroke back massage (SSBM) and acupressure on pruritus in patients undergoing HD.

Methods: In this clinical trial study, 50 patients with pruritus were randomly divided into two intervention groups. The interventions were performed three times a week for four weeks. The acupressure at SP10 and LI11 points and SSBM were performed for 10 minutes after HD. The Yosipovitch pruritus questionnaire and laboratory parameters form were used to collect data before and one week after the intervention.

Results: Acupressure and SSBM interventions caused significant changes in CRP and blood phosphorus levels, pruritus history, duration effect of antipruritic medications, sleep, quality-of-life, itch sensation and affective dimensions, daily activities, severity of pruritus, and location of pruritus. Nonetheless, the potassium levels in the serum did not show any notable alterations. Additionally, there was no noticeable distinction between groups in regard to any of the measured variables.

Conclusion: The results of our study suggest that both SSBM and acupressure could be beneficial as part of a comprehensive approach to managing pruritus in HD patients.